Interventions that delay or prevent transition to
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Very low quality evidence for omega 3 fatty acids and low to very low quality evidence for integrated psychotherapy also indicated that these interventions were associated with reductions in transition to psychosis at 12 months.Conclusions Although evidence of benefits for any specific intervention is not conclusive, these findings suggest that it might be possible to delay or prevent transition to psychosis. Further research should be undertaken to establish conclusively the potential for benefit of psychological interventions in the treatment of people at high risk of psychosis.IntroductionThe incidence of probable psychosis in community surveys in the United Kingdom appears to be stable, at about five per 1000 adults.  Schizophrenia is the most common form of psychosis and one of the leading causes of long term disability https://www.pandora-charm-uk.com/, affecting about 25 million people worldwide. Schizophrenia disrupts social and family relationships, resulting in severe educational and occupational impairment, lost productivity, unemployment, physical illness, and premature mortality. As a result, schizophrenia costs about 55000 (67500; $88000) per person per year in the UK.Schizophrenia is usually preceded by a prodromal period lasting one to three years. This period is characterised by a range of non specific behavioural and psychological symptoms, functional deterioration, and by both attenuated positive symptoms and brief limited intermittent psychotic symptoms (BLIPS). Among people at «ultra high risk» of psychosis, about 22% to 40% transition within 12 months. Interventions that delay or prevent transition to psychosis from this prodromal syndrome could be clinically and economically important.Antipsychotic drugs and family therapy could reduce the likelihood of relapse for established and first episode schizophrenia, and cognitive behavioural therapy (CBT) might reduce symptoms and hospital admission for people with schizophrenia. Combining these treatments in an integrated strategy might add substantial clinical and economic benefits for people with psychosis and early schizophrenia.